I have tried the memory settings, and the feature to turn the lockw on is set. I have not tried what stealth suggested, may be a little too in depth for me. lol, but thanks for the suggestions

 

Have you tried turning it off? Do the doors unlock when shifted in Park? Or just the driver's door if so set? Does any of the Personalization settings work?

Maybe the gear shifter switch is shot or gotten offset. I have never disassembled that part in my Caddy, so I cannot offer advise on that one.

 

I have tried turning it on and off. The only way it locks is by the actual lock or unlock button

 

My cad does that sometimes, just forgets to do it I guess. But it always seems to find a way to work itself out.